caa a22 4500 606247963 CHVBK 20210128101348.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s12262-015-1296-6 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1296-6 Serum Total Cholesterol Levels Would Predict Nosocomial Infections After Gastrointestinal Surgery [Elektronische Daten] [Mitsuaki Morimoto, Yoshikazu Nakamura, Yoshikazu Yasuda, Alan Lefor, Takashi Nagaie, Naohiro Sata, Yoshinori Hosoya, Hisanaga Horie, Koji Koinuma] It has been suggested that total cholesterol levels and the use of statin medications are associated with the incidence of complications after gastrointestinal surgery. The aim of this study was to determine if preoperative total cholesterol levels are associated with a higher risk of postoperative infections and mortality. A total of 2211 patients undergoing general surgical procedures between December 2006 and November 2008 at Iizuka Hospital and between January 2010 and March 2012 at Jichi Medical University Hospital were reviewed. Multiple logistic regression models were used to evaluate serum total cholesterol and other variables as predictors of postoperative nosocomial infections. Serum total cholesterol concentrations lower than 160mg/dl were associated with an increased incidence of superficial and deep incisional surgical site infections. Serum total cholesterol levels showed a reverse J-shaped relationship with the development of organ space surgical site infection and pneumonia. There was no discernible effect of serum cholesterol levels on the postoperative mortality observed in this cohort of patients. Decreased serum albumin was one of the strongest risk factors for the development of nosocomial infection after surgery. Postoperative pneumonia was not observed in patients taking statin medications whose cholesterol levels were <200mg/dl. Serum total cholesterol may be a valid predictor of surgical outcome. Preoperative statin use may affect the development of postoperative pneumonia in patients with total cholesterol levels below 200mg/dl. Association of Surgeons of India, 2015 Pneumonia nationallicence Surgical site infections nationallicence Statins nationallicence Total cholesterol nationallicence Morimoto Mitsuaki Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Nakamura Yoshikazu Department of Public Health, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Yasuda Yoshikazu Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Lefor Alan Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Nagaie Takashi Department of Surgery, Iizuka Hospital, 3-83 Yoshio-machi, 820-8505, Iizuka, Fukuoka, Japan aut Sata Naohiro Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Hosoya Yoshinori Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Horie Hisanaga Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Koinuma Koji Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Indian Journal of Surgery Springer India 77/4(2015-08-01), 283-289 0972-2068 77:4<283 2015 77 12262 https://doi.org/10.1007/s12262-015-1296-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1296-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morimoto Mitsuaki Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Nakamura Yoshikazu Department of Public Health, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Yasuda Yoshikazu Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Lefor Alan Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Nagaie Takashi Department of Surgery, Iizuka Hospital, 3-83 Yoshio-machi, 820-8505, Iizuka, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sata Naohiro Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Hosoya Yoshinori Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Horie Hisanaga Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Koinuma Koji Department of Gastrointestinal Surgery, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/4(2015-08-01), 283-289 0972-2068 77:4<283 2015 77 12262