caa a22 4500 606248072 CHVBK 20210128101348.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s12262-015-1369-6 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1369-6 Tewari M. Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India aut Pancreatic Cancer: a Challenge to Cure [Elektronische Daten] [M. Tewari] Pancreatic ductal adenocarcinoma (PDA) is a challenging disease, as overall survival has not improved over the last several decades. The disease is characterized by late diagnosis, difficult major surgery in resectable patients, and a biologically chemoresistant tumor. Intense research in the field is ongoing to develop biomarkers for early detection and prognostication. Surgery is presently the crux of the management of PDA and has been standardized over the years with high-volume centers reporting <5% operative mortality. The biggest problem is to overcome the inherent chemoresistance of the tumor that is densely fibrotic and hypoxic and has a tendency to invade surrounding neuronal plexuses. This review attempts to summarize in brief the reasons why PDA is difficult to treat, and provides a glimpse of the ongoing research in the field. Association of Surgeons of India, 2015 Pancreatic ductal adenocarcinoma nationallicence Diagnosis nationallicence Surgery nationallicence Chemoresistance nationallicence Survival nationallicence Indian Journal of Surgery Springer India 77/5(2015-10-01), 350-357 0972-2068 77:5<350 2015 77 12262 https://doi.org/10.1007/s12262-015-1369-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1369-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Tewari M. Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/5(2015-10-01), 350-357 0972-2068 77:5<350 2015 77 12262