caa a22 4500 606248110 CHVBK 20210128101348.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s12262-015-1362-0 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1362-0 Surgical Management of Chronic Pancreatitis [Elektronische Daten] [Dilip Parekh, Sathima Natarajan] Advances over the past decade have indicated that a complex interplay between environmental factors, genetic predisposition, alcohol abuse, and smoking lead towards the development of chronic pancreatitis. Chronic pancreatitis is a complex disorder that causes significant and chronic incapacity in patients and a substantial burden on the society. Major advances have been made in the etiology and pathogenesis of this disease and the role of genetic predisposition is increasingly coming to the fore. Advances in noninvasive diagnostic modalities now allow for better diagnosis of chronic pancreatitis at an early stage of the disease. The impact of these advances on surgical treatment is beginning to emerge, for example, patients with certain genetic predispositions may be better treated with total pancreatectomy versus lesser procedures. Considerable controversy remains with respect to the surgical management of chronic pancreatitis. Modern understanding of the neurobiology of pain in chronic pancreatitis suggests that a window of opportunity exists for effective treatment of the intractable pain after which central sensitization can lead to an irreversible pain syndrome in patients with chronic pancreatitis. Effective surgical procedures exist for chronic pancreatitis; however, the timing of surgery is unclear. For optimal treatment of patients with chronic pancreatitis, close collaboration between a multidisciplinary team including gastroenterologists, surgeons, and pain management physicians is needed. Association of Surgeons of India, 2015 Chronic pancreatitis nationallicence Surgery nationallicence Frey nationallicence Neuropathic pain nationallicence Total pancreatectomy nationallicence Puestow nationallicence Parekh Dilip Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 90033, Los Angeles, CA, USA aut Natarajan Sathima Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 90033, Los Angeles, CA, USA aut Indian Journal of Surgery Springer India 77/5(2015-10-01), 453-469 0972-2068 77:5<453 2015 77 12262 https://doi.org/10.1007/s12262-015-1362-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1362-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parekh Dilip Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Natarajan Sathima Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/5(2015-10-01), 453-469 0972-2068 77:5<453 2015 77 12262