caa a22 4500 606248188 CHVBK 20210128101349.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s12262-015-1364-y doi (NATIONALLICENCE)springer-10.1007/s12262-015-1364-y Vascular Resection in Pancreatic Cancer [Elektronische Daten] [Ruzica Luketina, Thilo Hackert, Markus Büchler] Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant tumors and represents the fifth most common cause of cancer-related deaths. It is associated with a poor prognosis, likely due to the tendency of the tumor for early local and distant spread. One of the major obstacles of effectively treating PDAC is the often late diagnosis. Among all options currently available for PDAC, surgical resection offers the only potential cure with 5-year survival rate of approximately 15-20%. However, in the absence of metastatic disease, which precludes resection, assessment of vascular invasion is an important parameter for determining resectability for pancreatic cancer. The vascular involvement in patients with pancreatic carcinoma ranges between 21 and 64%. Historically, vascular involvement has been considered a contraindication to resective cure. Meanwhile, the surgical approach of pancreatoduodenectomy (PD) combined with vascular resection and reconstruction has been widely applied in clinical practice to remove the tumor completely. Therefore, vascular invasion is no longer a surgical contraindication and the rate of surgical resection has greatly increased. Moreover, PD combined with vascular resection can account for 20 to 25% of the total cases of PD surgery in a number of the larger pancreas treatment centers. The aim of this review is to provide an overview of management and outcome of vascular resection in PDAC surgery. Association of Surgeons of India, 2015 Pancreatic cancer nationallicence Vascular resection nationallicence Borderline resectability nationallicence Pancreatic surgery nationallicence Luketina Ruzica Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut Hackert Thilo Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut Büchler Markus Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut Indian Journal of Surgery Springer India 77/5(2015-10-01), 381-386 0972-2068 77:5<381 2015 77 12262 https://doi.org/10.1007/s12262-015-1364-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1364-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luketina Ruzica Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Hackert Thilo Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Büchler Markus Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77/5(2015-10-01), 381-386 0972-2068 77:5<381 2015 77 12262