caa a22 4500 60624834X CHVBK 20210128101350.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-015-1270-3 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1270-3 Association Between Time (Initiation and Length) and Oncological Outcomes for the Patients with Colon Cancer Treated with Adjuvant Chemotherapy [Elektronische Daten] [In Jeong, Jong Yoo, Sang Seo, Min An, Kwang Kim, Ki Bae, Chang Choi, Jin Hwang, Ji Kim, Mi Kang, Min Oh, Kwan Hong] Adjuvant chemotherapy is benefit for high-risk stage II and stage III colon cancer after curative resection. But, the optimal time between surgical and initiation of adjuvant chemotherapy remains unclear. Moreover, no study of efficacy with different lengths of adjuvant chemotherapy has appeared. This study was aimed to identify association between time (initiation and length) and oncological outcomes of adjuvant chemotherapy on the stages II and III colon cancer patients. A total of 406 high-risk stages II and III colon cancer patients were retrospectively enrolled in prospectively collected data. They were categorized into three groups representing chemotherapy initiation time: less than 4weeks (group 1), 4 to 6weeks (group 2), and more than 6weeks (group 3). They were categorized into two groups representing chemotherapy length time : less than 200days (group 1a) and more than 200days (group 2a). The 5-year disease-free survival (DFS) rates were 74.97% in group 1, 76.94% in group 2, and 63.97% in group 3 (p > 0.05). The 5-year DFS rates were 75.49% in the group that received adjuvant chemotherapy within 6weeks and 63.97% in the group that received adjuvant chemotherapy >6weeks (p = 0.0539). The 5-year DFS rates were 77.21% in group 1a and 81.82% in group 2a (p > 0.05). Adjuvant chemotherapy should be safely offered within 6weeks after surgical excision in patients with colon cancer after considering the patient's general physical condition and hematological factors, even if the chemotherapy length is prolonged. Association of Surgeons of India, 2015 Colon cancer nationallicence Adjuvant chemotherapy nationallicence Oncological outcome nationallicence Time nationallicence Jeong In Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut Yoo Jong Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut Seo Sang Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut An Min Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut Kim Kwang Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut Bae Ki Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut Choi Chang Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut Hwang Jin Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut Kim Ji Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut Kang Mi Department of Pathology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut Oh Min Department of Clinical Trial Center in Pharmacology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut Hong Kwan Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut Indian Journal of Surgery Springer India 77(2015-12-01), 1252-1257 0972-2068 77<1252 2015 77 12262 https://doi.org/10.1007/s12262-015-1270-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1270-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jeong In Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 700 1- Yoo Jong Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 700 1- Seo Sang Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 700 1- An Min Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 700 1- Kim Kwang Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 700 1- Bae Ki Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 700 1- Choi Chang Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 700 1- Hwang Jin Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Kim Ji Department of Internal Medicine, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Kang Mi Department of Pathology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Oh Min Department of Clinical Trial Center in Pharmacology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Hong Kwan Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 75 Bokji-ro, Busanjin-gu, 614-735, Busan, Korea aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 1252-1257 0972-2068 77<1252 2015 77 12262