caa a22 4500 60624851X CHVBK 20210128101350.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-013-1025-y doi (NATIONALLICENCE)springer-10.1007/s12262-013-1025-y Pentoxifylline Increases Antiadhesion Effect of Streptokinase on Postoperative Adhesion Formation: Involvement of Fibrinolytic Pathway [Elektronische Daten] [Majid Jafari-Sabet, Azita Shishegar, Ali-Reza Saeedi, Siavash Ghahari] Pentoxifylline reduces peritoneal adhesions and increases peritoneal fibrinolysis in rodents. Furthermore, the activation of the fibrinolytic system by streptokinase leading to degradation of fibrin is effective in the prevention of adhesion formation. We have investigated the effects of pentoxifylline and streptokinase alone and/or coadministration on postoperative intra-abdominal adhesion formation in adult female NMRI mice. Drugs were administered from the day of surgery until 10days after surgery. At relaparotomy 11days after surgery, the abdomen was opened, and the adhesions were graded in a blinded fashion utilizing the classification system described. Oral gavage administration of lower doses of pentoxifylline (3.125, 6.25, and 12.5mg/kg) had no significant effect on postsurgical adhesion formation, while the higher doses of pentoxifylline (25 and 50mg/kg) significantly decreased postsurgical adhesion formation. Moreover, intraperitoneal injection of lower doses of streptokinase (9.375, 18.75, and 37.5unit/kg, i.p.) had no significant effect on postsurgical adhesion formation, while the higher doses of streptokinase (75 and 150unit/kg) significantly decreased postsurgical adhesion formation. In other series of experiments, coadministration of lower doses of pentoxifylline and streptokinase doses, which were ineffective when given alone, significantly decreased postsurgical intra-abdominal adhesion formation compared with streptokinase control group. The results suggest that pentoxifylline may interfere with streptokinase in the reduction of postoperative intra-abdominal adhesion formation by enhancing local fibrinolytic activity. Association of Surgeons of India, 2014 Pentoxifylline nationallicence Streptokinase nationallicence Postoperative intra-abdominal adhesions nationallicence Adhesion formation nationallicence Mice nationallicence Jafari-Sabet Majid Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut Shishegar Azita Department of Surgery, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut Saeedi Ali-Reza Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut Ghahari Siavash Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut Indian Journal of Surgery Springer India 77(2015-12-01), 837-842 0972-2068 77<837 2015 77 12262 https://doi.org/10.1007/s12262-013-1025-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-013-1025-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jafari-Sabet Majid Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Shishegar Azita Department of Surgery, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Saeedi Ali-Reza Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Ghahari Siavash Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 837-842 0972-2068 77<837 2015 77 12262