caa a22 4500 606248595 CHVBK 20210128101351.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-015-1261-4 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1261-4 Adjuvant Intrahepatic Injection Iodine-131-Lipiodol Improves Prognosis of Patients with Hepatocellular Carcinoma After Resection: a Meta-Analysis [Elektronische Daten] [Ye Hong, Lu-Peng Wu, Feng Ye, Yan-Ming Zhou] High incidence of intrahepatic recurrence is a major surgical limitation following hepatectomy of hepatocellular carcinoma (HCC). This study was intended to investigate the effects of adjuvant intrahepatic injection of iodine-131-lipiodol on disease recurrence and survival in patients with HCC who underwent resection. A computerized literature search was performed to identify relevant articles. Data synthesis was performed using Review Manager 5.0 software, and results are presented as odds ratio (OR) with 95% confidence intervals. Two randomized controlled trials and three case-control studies with a total of 334 participants were analyzed. Iodine-131-lipiodol treatment achieved significantly lower rates of intrahepatic recurrence (OR = 0.48, 95% confidence interval (95% CI) = 0.30-0.74; P = 0.001) and early recurrence (<2year) (OR = 0.45, 95% CI = 0.23-0.89; P = 0.02). Likewise, iodine-131-lipiodol treatment improved both the 5-year disease-free survival and overall survival significantly (OR = 1.85, 95% CI = 1.13-3.03; P = 0.01; OR = 2.00, 95% CI = 0.99-4.04; P = 0.05, respectively). Adjuvant intrahepatic injection of iodine-131-lipiodol resulted in a preventive effect on recurrence and improved survival after resection of HCC. Further larger, multi-centred, randomized prospective trial is warranted. Association of Surgeons of India, 2015 Hepatocellular carcinoma nationallicence Iodine-131-lipiodol nationallicence Recurrence nationallicence Prognosis nationallicence Hong Ye Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut Wu Lu-Peng Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut Ye Feng Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut Zhou Yan-Ming Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut Indian Journal of Surgery Springer India 77(2015-12-01), 1227-1232 0972-2068 77<1227 2015 77 12262 https://doi.org/10.1007/s12262-015-1261-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1261-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hong Ye Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut NATIONALLICENCE 700 1- Wu Lu-Peng Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut NATIONALLICENCE 700 1- Ye Feng Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut NATIONALLICENCE 700 1- Zhou Yan-Ming Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, 55 Zhenhai Road, 361003, Xiamen, China aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 1227-1232 0972-2068 77<1227 2015 77 12262