caa a22 4500 606248870 CHVBK 20210128101352.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-015-1264-1 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1264-1 Efficacy and Safety of Propiverine Hydrochloride for Overactive Bladder in Adult: a Systematic Review and Meta-analysis [Elektronische Daten] [Wei Huang, Huantao Zong, Xin Zhou, Tao Wang, Yong Zhang] We carried out a systematic review and meta-analysis to assess the efficacy and safety of propiverine for treating overactive bladder (OAB) in adult. A literature review was performed to identify all published randomized placebo-controlled trials (RCT) of propiverine for the treatment of OAB. The search included the following databases: PUBMED and EMBASE. The reference lists of retrieved studies were also investigated. A systematic review and meta-analysis were conducted. Ten publications involving nine different RCTs were used in the analysis. We found that propiverine was effective in treating OAB in our meta-analysis. The decrease in number of micturitions/24h (P < 0.00001, the mean decrease was from 1.80 to 2.57) indicated that propiverine was more effective than the placebo. Propiverine also decrease the number of urgency, urgency incontinence, and nocturia and increase urine volume. However, the incidence of difficulty in voiding was higher with propiverine therapy compared with the placebo (P = 0.05, the mean percentage range from 0.34 to 4.93%). The decrease of total international prostate symptom score (IPSS) (P < 0.0001, the mean decrease was from 12.5 to 16.1) indicated that propiverine add a1-adrenoceptor antagonist was more effective in decreasing the lower urinary tract symptom (LUTS). The combination therapy also decreases the voiding symptom and storage symptom scores and increases maximum flow rate. This meta-analysis shows that propiverine is a safe and effective treatment for OAB. The major adverse event associated with propiverine treatment was difficulty in voiding. Propiverine add a1-adrenoceptor antagonist was more effective in terms of decreasing difficulty in voiding. Association of Surgeons of India, 2015 Propiverine nationallicence Overactive bladder nationallicence Alpha-blockers nationallicence Meta-analysis nationallicence Randomized controlled trials nationallicence Huang Wei Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut Zong Huantao Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut Zhou Xin Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut Wang Tao Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut Zhang Yong Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut Indian Journal of Surgery Springer India 77(2015-12-01), 1369-1377 0972-2068 77<1369 2015 77 12262 https://doi.org/10.1007/s12262-015-1264-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1264-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Wei Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut NATIONALLICENCE 700 1- Zong Huantao Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut NATIONALLICENCE 700 1- Zhou Xin Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut NATIONALLICENCE 700 1- Wang Tao Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut NATIONALLICENCE 700 1- Zhang Yong Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, No. 6 Tiantan Xi Li, 100050, Beijing, Dongcheng District, China aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 1369-1377 0972-2068 77<1369 2015 77 12262