caa a22 4500 606248943 CHVBK 20210128101353.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s12262-015-1273-0 doi (NATIONALLICENCE)springer-10.1007/s12262-015-1273-0 Abdominoperineal Excisions in the Treatment Regimen for Advanced and Recurrent Vulvar Cancers—Analysis of a Single-Centre Experience [Elektronische Daten] [Sabine Hannes, Johanna Nijboer, Alexander Reinisch, Wolf Bechstein, Nils Habbe] Vulva cancer is the fourth leading gynaecological malignancy, accounting for approximately 4% of all gynaecological cancers. Surgery represents the treatment of choice, and cases of advanced or recurrent vulvar cancers are to date a major challenge to multidisciplinary teams. Abdominoperineal excision (APE) in combination with vulvectomy and inguinal lymphadenectomy is the only curative treatment option. Patients' files of all women with squamous cell carcinoma of the vulva who underwent abdominoperineal resection were retrospectively reviewed with special regards to technical challenges the general surgeon will face. Seven women were enrolled in this retrospective study with a median age of 71years (range 56-79years). In six patients, the pelvic floor after abdominoperineal excision could be closed by direct suture of the levator muscles. One woman underwent abdominoperineal resection with closure of the defect using a vertical rectus abdominis myocutaneous (VRAM) flap. All women underwent radical vulvectomy, in five patients in combination with bilateral inguinal lymph node dissection. Operation time was 377min (range 130-505min). The median overall survival after surgery was 27months (range 4-84months), with a calculated 5-year survival rate of 42%. Women with negative lymph nodes revealed a longer survival time after surgery compared to women with lymph node metastases (15.5 vs. 72months; p = 0.09). Abdominoperineal excisions represent a powerful tool in the multidisciplinary treatment regimen of advanced or recurrent vulvar cancer. Reconstruction of the pelvic floor usually does not require myocutaneous flaps, even when facing large tumours. Despite high complication rates, radical surgery was a feasible treatment with long-term survival potential without mortality. Association of Surgeons of India, 2015 Vulvar cancer nationallicence Abdominoperineal excision nationallicence Salvage surgery nationallicence Exenteration nationallicence Gynaecological cancer nationallicence Hannes Sabine Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut Nijboer Johanna Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut Reinisch Alexander Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut Bechstein Wolf Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut Habbe Nils Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut Indian Journal of Surgery Springer India 77(2015-12-01), 1270-1274 0972-2068 77<1270 2015 77 12262 https://doi.org/10.1007/s12262-015-1273-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s12262-015-1273-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hannes Sabine Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut NATIONALLICENCE 700 1- Nijboer Johanna Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut NATIONALLICENCE 700 1- Reinisch Alexander Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut NATIONALLICENCE 700 1- Bechstein Wolf Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut NATIONALLICENCE 700 1- Habbe Nils Department of General- and Visceral Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut NATIONALLICENCE 773 0- Indian Journal of Surgery Springer India 77(2015-12-01), 1270-1274 0972-2068 77<1270 2015 77 12262