D-Glucosamine supplementation extends life span of nematodes and of ageing mice: 10.1038/ncomms4563
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| 001 | 528785753 | ||
| 005 | 20190713030955.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 180924s2014 xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.3929/ethz-b-000083876 |2 doi |
| 024 | 7 | 0 | |a 10.1038/ncomms4563 |2 doi |
| 035 | |a (ETHRESEARCH)oai:www.research-collecti.ethz.ch:20.500.11850/83876 | ||
| 245 | 0 | 0 | |a D-Glucosamine supplementation extends life span of nematodes and of ageing mice: 10.1038/ncomms4563 |h [Elektronische Daten] |c [Sandra Weimer, Josephine Priebs, Doreen Kuhlow, Marco Groth, Steffen Priebe, Johannes Mansfeld, Troy L. Merry, Sébastien Dubuis, Beate Laube, Andreas F. Pfeiffer, Tim J. Schulz, Reinhard Guthke, Matthias Platzer, Nicola; id_orcid 0000-0003-1271-1021 Zamboni, Kim Zarse, Michael; id_orcid 0000-0003-2109-2453 Ristow] |
| 246 | 0 | |a Nat Commun | |
| 506 | |a Open access |2 ethresearch | ||
| 520 | 3 | |a D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that activates AMP-activated protein kinase (AMPK/AAK-2) and increases mitochondrial biogenesis. Consistent with the concept of mitohormesis, GlcN promotes increased formation of mitochondrial reactive oxygen species (ROS) culminating in increased expression of the nematodal amino acid-transporter 1 (aat-1) gene. Ameliorating mitochondrial ROS formation or impairment of aat-1-expression abolishes GlcN-mediated life span extension in an NRF2/SKN-1-dependent fashion. Unlike other calorie restriction mimetics, such as 2-deoxyglucose, GlcN extends life span of ageing C57BL/6 mice, which show an induction of mitochondrial biogenesis, lowered blood glucose levels, enhanced expression of several murine amino-acid transporters, as well as increased amino-acid catabolism. Taken together, we provide evidence that GlcN extends life span in evolutionary distinct species by mimicking a low-carbohydrate diet. | |
| 540 | |a Creative Commons Attribution 3.0 Unported |u http://creativecommons.org/licenses/by/3.0 |2 ethresearch | ||
| 700 | 1 | |a Weimer |D Sandra |e joint author | |
| 700 | 1 | |a Priebs |D Josephine |e joint author | |
| 700 | 1 | |a Kuhlow |D Doreen |e joint author | |
| 700 | 1 | |a Groth |D Marco |e joint author | |
| 700 | 1 | |a Priebe |D Steffen |e joint author | |
| 700 | 1 | |a Mansfeld |D Johannes |e joint author | |
| 700 | 1 | |a Merry |D Troy L. |e joint author | |
| 700 | 1 | |a Dubuis |D Sébastien |e joint author | |
| 700 | 1 | |a Laube |D Beate |e joint author | |
| 700 | 1 | |a Pfeiffer |D Andreas F. |e joint author | |
| 700 | 1 | |a Schulz |D Tim J. |e joint author | |
| 700 | 1 | |a Guthke |D Reinhard |e joint author | |
| 700 | 1 | |a Platzer |D Matthias |e joint author | |
| 700 | 1 | |a Zamboni |D Nicola; id_orcid 0000-0003-1271-1021 |e joint author | |
| 700 | 1 | |a Zarse |D Kim |e joint author | |
| 700 | 1 | |a Ristow |D Michael; id_orcid 0000-0003-2109-2453 |e joint author | |
| 773 | 0 | |t Nature Communications |d London : Nature Publishing Group |g 5, p. 3563 |x 2041-1723 | |
| 856 | 4 | 0 | |u http://hdl.handle.net/20.500.11850/83876 |q text/html |z WWW-Backlink auf das Repository (Open access) |
| 908 | |D 1 |a Journal Article |2 ethresearch | ||
| 950 | |B ETHRESEARCH |P 856 |E 40 |u http://hdl.handle.net/20.500.11850/83876 |q text/html |z WWW-Backlink auf das Repository (Open access) | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Weimer |D Sandra |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Priebs |D Josephine |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Kuhlow |D Doreen |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Groth |D Marco |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Priebe |D Steffen |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Mansfeld |D Johannes |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Merry |D Troy L. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Dubuis |D Sébastien |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Laube |D Beate |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Pfeiffer |D Andreas F. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Schulz |D Tim J. |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Guthke |D Reinhard |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Platzer |D Matthias |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Zamboni |D Nicola; id_orcid 0000-0003-1271-1021 |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Zarse |D Kim |e joint author | ||
| 950 | |B ETHRESEARCH |P 700 |E 1- |a Ristow |D Michael; id_orcid 0000-0003-2109-2453 |e joint author | ||
| 950 | |B ETHRESEARCH |P 773 |E 0- |t Nature Communications |d London : Nature Publishing Group |g 5, p. 3563 |x 2041-1723 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ETHRESEARCH |F ETHRESEARCH |b ETHRESEARCH |j Journal Article |c Open access | ||