Local infiltration analgesia following total knee arthroplasty: effect on post-operative pain and opioid consumption—a meta-analysis
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| 024 | 7 | 0 | |a 10.1007/s00167-013-2788-1 |2 doi |
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| 245 | 0 | 0 | |a Local infiltration analgesia following total knee arthroplasty: effect on post-operative pain and opioid consumption—a meta-analysis |h [Elektronische Daten] |c [Renée Keijsers, Rogier van Delft, Michel van den Bekerom, Dirk de Vries, Richard Brohet, Peter Nolte] |
| 520 | 3 | |a Introduction: Local infiltration analgesia (LIA) is a popular method for decreasing post-operative pain after total knee arthroplasty (TKA). The goal of this meta-analysis is to compare the effect of LIA with placebo on the intensity of post-operative pain and the consumption of opioids. Methods: A search was performed in the PubMed/MEDLINE, Cochrane, EMBASE and TRIP databases. All (quasi)-randomized controlled trials (RCTs) were included. LIA consists of intra-operative infiltration with at least one analgesic component. Data were pooled using Cochrane software. Results: Seven placebo-controlled RCTs were included, involving 405 TKAs. On the first post-operative day, LIA provides an average decrease in VAS scores at rest of 12.3% compared to placebo. Six RCTs studied opioid consumption in patients following TKA. There was a decrease in opioid consumption of 14.8% compared to placebo 24h after surgery. This suggests a reduced pain perception due to LIA. On the second post-operative day, the effect on both outcome measures was diminished and no longer significant. Heterogeneity between the studies was 71% for pain and 39% for opioid consumption (p=0.002 and p=0.0005). No major complications were reported with the use of LIA. Conclusion: LIA might be able to decrease pain and the use of opioids on the first post-operative day following TKA. However, due to the high level of heterogeneity between the studies, no firm conclusions can be drawn. Level of evidence: Meta-analysis, Level II. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2013 | ||
| 690 | 7 | |a Knee arthroplasty |2 nationallicence | |
| 690 | 7 | |a Analgesia |2 nationallicence | |
| 690 | 7 | |a Post-operative pain |2 nationallicence | |
| 690 | 7 | |a Meta-analysis |2 nationallicence | |
| 700 | 1 | |a Keijsers |D Renée |u Department of Orthopaedic Surgery, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | |
| 700 | 1 | |a van Delft |D Rogier |u Departement of Anesthesiology, Leids Universitair Medisch Centrum, P.O.Box 9600, 2300RC, Leiden, The Netherlands |4 aut | |
| 700 | 1 | |a van den Bekerom |D Michel |u Department of Orthopaedic Surgery, O.L.V.G., P.O. Box 95500, 1090 HM, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a de Vries |D Dirk |u Department of Anesthesiology, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | |
| 700 | 1 | |a Brohet |D Richard |u Research Center Linnaeus Insititute, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | |
| 700 | 1 | |a Nolte |D Peter |u Department of Orthopaedic Surgery, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | |
| 773 | 0 | |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/7(2015-07-01), 1956-1963 |x 0942-2056 |q 23:7<1956 |1 2015 |2 23 |o 167 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00167-013-2788-1 |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00167-013-2788-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Keijsers |D Renée |u Department of Orthopaedic Surgery, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Delft |D Rogier |u Departement of Anesthesiology, Leids Universitair Medisch Centrum, P.O.Box 9600, 2300RC, Leiden, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van den Bekerom |D Michel |u Department of Orthopaedic Surgery, O.L.V.G., P.O. Box 95500, 1090 HM, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a de Vries |D Dirk |u Department of Anesthesiology, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Brohet |D Richard |u Research Center Linnaeus Insititute, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nolte |D Peter |u Department of Orthopaedic Surgery, Spaarne Hospital, P.O. Box 770, 2130 AT, Hoofddorp, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Knee Surgery, Sports Traumatology, Arthroscopy |d Springer Berlin Heidelberg |g 23/7(2015-07-01), 1956-1963 |x 0942-2056 |q 23:7<1956 |1 2015 |2 23 |o 167 | ||