Supraphysiological 25-hydroxy vitamin D3 level at admission is associated with illness severity and mortality in critically ill patients
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0585-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0585-7 | ||
| 245 | 0 | 0 | |a Supraphysiological 25-hydroxy vitamin D3 level at admission is associated with illness severity and mortality in critically ill patients |h [Elektronische Daten] |c [Ravikar Ralph, John Peter, Anugrah Chrispal, Anand Zachariah, Joseph Dian, Tunny Sebastian, Bala Venkatesh, Kurien Thomas] |
| 520 | 3 | |a We studied the association between admission serum 25-hydroxy vitamin D3 level and in-hospital mortality in a prospective cohort of critically ill patients admitted to the medical intensive care unit of a tertiary care referral center. Of the 180 patients enrolled, 129 were included. Vitamin D3 deficiency was observed in 37% (n=48) and supra-physiological levels (≥250nmol/L) in 15.5% (n=20). Patients with supraphysiological vitamin D3 levels were grouped as outliers. There was no difference in mortality (p=0.41) between vitamin D3 deficient (21/48) and non-deficient (36/81) patients in analysis with and without outliers. Patients with vitamin D3 ≥250nmol/L had a significantly higher (p=0.02) Simplified Acute Physiology Score (SAPS) II and mortality (p=0.003) [mean (SD) 60.1±17.1 and 75% (15/20), respectively] when compared with the rest [45.6±18 and 38.5% (42/109), respectively]. The sensitivity, specificity and SAPS II independent odds ratio to predict mortality in patients with supraphysiological vitamin D3 levels were 26.3, 93.1 and 3.7% (95% confidence interval 1.2-11.4; p=0.03), respectively. In conclusion, vitamin D3 deficiency in our cohort was not associated with mortality. A patient subset with supra-physiological vitamin D levels had higher illness severity scores and mortality. Extrinsic factors interfering with test results were ruled out. A biological hypothesis to explain this observation is proposed. Further clarification of mechanisms leading to this observation is warranted. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a 25-Hydroxyvitamin D |2 nationallicence | |
| 690 | 7 | |a Critical illness |2 nationallicence | |
| 690 | 7 | |a SAPS II score |2 nationallicence | |
| 690 | 7 | |a Mortality |2 nationallicence | |
| 700 | 1 | |a Ralph |D Ravikar |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | |
| 700 | 1 | |a Peter |D John |u Medical Intensive Care Unit, CMCH, Vellore, India |4 aut | |
| 700 | 1 | |a Chrispal |D Anugrah |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | |
| 700 | 1 | |a Zachariah |D Anand |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | |
| 700 | 1 | |a Dian |D Joseph |u Department of Clinical Biochemistry, CMCH, Vellore, India |4 aut | |
| 700 | 1 | |a Sebastian |D Tunny |u Department of Biostatistics, CMCH, Vellore, India |4 aut | |
| 700 | 1 | |a Venkatesh |D Bala |u Department of Intensive Care, The University of Queensland, St Lucia, Australia |4 aut | |
| 700 | 1 | |a Thomas |D Kurien |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 239-243 |x 0914-8779 |q 33:2<239 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0585-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a brief-communication |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0585-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ralph |D Ravikar |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Peter |D John |u Medical Intensive Care Unit, CMCH, Vellore, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chrispal |D Anugrah |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zachariah |D Anand |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dian |D Joseph |u Department of Clinical Biochemistry, CMCH, Vellore, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sebastian |D Tunny |u Department of Biostatistics, CMCH, Vellore, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Venkatesh |D Bala |u Department of Intensive Care, The University of Queensland, St Lucia, Australia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Thomas |D Kurien |u Department of Medicine, Christian Medical College Hospital (CMCH), Vellore, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 239-243 |x 0914-8779 |q 33:2<239 |1 2015 |2 33 |o 774 | ||