The association between genetic variants of RUNX2 , ADIPOQ and vertebral fracture in Korean postmenopausal women
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| 024 | 7 | 0 | |a 10.1007/s00774-014-0570-1 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00774-014-0570-1 | ||
| 245 | 0 | 4 | |a The association between genetic variants of RUNX2 , ADIPOQ and vertebral fracture in Korean postmenopausal women |h [Elektronische Daten] |c [Kyong-Chol Kim, Hyejin Chun, ChaoQiang Lai, Laurence Parnell, Yangsoo Jang, Jongho Lee, Jose. Ordovas] |
| 520 | 3 | |a Contrary to the traditional belief that obesity acts as a protective factor for bone, recent epidemiologic studies have shown that body fat might be a risk factor for osteoporosis and bone fracture. Accordingly, we evaluated the association between the phenotypes of osteoporosis or vertebral fracture and variants of obesity-related genes, peroxisome proliferator-activated receptor-gamma (PPARG), runt-related transcription factor 2 (RUNX2), leptin receptor (LEPR), and adiponectin (ADIPOQ). In total, 907 postmenopausal healthy women, aged 60-79years, were included in this study. BMD and biomarkers of bone health and adiposity were measured. We genotyped for four single nucleotide polymorphisms (SNPs) from four genes (PPARG, RUNX2, LEPR, ADIPOQ). A general linear model for continuous dependent variables and a logistic regression model for categorical dependent variables were used to analyze the statistical differences among genotype groups. Compared with the TT subjects at rs7771980 in RUNX2, C-carrier (TC+CC) subjects had a lower vertebral fracture risk after adjusting for age, smoking, alcohol, total calorie intake, total energy expenditure, total calcium intake, total fat intake, weight, body fat. Odds ratio (OR) and 95% interval (CI) for the vertebral fracture risk was 0.55 (95% CI 0.32-0.94). After adjusting for multiple variables, the prevalence of vertebral fracture was highest in GG subjects at rs1501299 in ADIPOQ (p=0.0473). A high calcium intake (>1000mg/day) contributed to a high bone mineral density (BMD) in GT+TT subjects at rs1501299 in ADIPOQ (p for interaction=0.0295). Even if the mechanisms between obesity-related genes and bone health are not fully established, the results of our study revealed the association of certain SNPs from obesity-related genes with BMD or vertebral fracture risk in postmenopausal Korean women. | |
| 540 | |a The Japanese Society for Bone and Mineral Research and Springer Japan, 2014 | ||
| 690 | 7 | |a Polymorphisms |2 nationallicence | |
| 690 | 7 | |a Runt-related transcription factor 2 ( RUNX2 ) |2 nationallicence | |
| 690 | 7 | |a Adiponectin ( ADIPOQ) |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Vertebral fracture |2 nationallicence | |
| 700 | 1 | |a Kim |D Kyong-Chol |u Department of Family Medicine, Chaum Hospital, Cha University, Seoul, Korea |4 aut | |
| 700 | 1 | |a Chun |D Hyejin |u Health Promotion Center, Ewha Woman's University Mokdong Hospital Ewha Woman's University School of Medicine, Seoul, Korea |4 aut | |
| 700 | 1 | |a Lai |D ChaoQiang |u Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Parnell |D Laurence |u Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Jang |D Yangsoo |u Graduate Program in Science for Aging, Yonsei University, Seoul, Korea |4 aut | |
| 700 | 1 | |a Lee |D Jongho |u Graduate Program in Science for Aging, Yonsei University, Seoul, Korea |4 aut | |
| 700 | 1 | |a Ordovas |D Jose |u Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA |4 aut | |
| 773 | 0 | |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 173-179 |x 0914-8779 |q 33:2<173 |1 2015 |2 33 |o 774 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00774-014-0570-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00774-014-0570-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Kyong-Chol |u Department of Family Medicine, Chaum Hospital, Cha University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chun |D Hyejin |u Health Promotion Center, Ewha Woman's University Mokdong Hospital Ewha Woman's University School of Medicine, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lai |D ChaoQiang |u Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Parnell |D Laurence |u Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jang |D Yangsoo |u Graduate Program in Science for Aging, Yonsei University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Jongho |u Graduate Program in Science for Aging, Yonsei University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ordovas |D Jose |u Nutritional Genomics Lab, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Bone and Mineral Metabolism |d Springer Japan |g 33/2(2015-03-01), 173-179 |x 0914-8779 |q 33:2<173 |1 2015 |2 33 |o 774 | ||