Measuring quantitative autism traits in families: informant effect or intergenerational transmission?
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| 005 | 20210128100359.0 | ||
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| 008 | 210128e20150401xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00787-014-0586-z |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00787-014-0586-z | ||
| 245 | 0 | 0 | |a Measuring quantitative autism traits in families: informant effect or intergenerational transmission? |h [Elektronische Daten] |c [Wouter De la Marche, Ilse Noens, Sofie Kuppens, Jantine Spilt, Bart Boets, Jean Steyaert] |
| 520 | 3 | |a Autism spectrum disorders (ASD) have a high degree of heritability, but there is still much debate about specific causal genes and pathways. To gain insight into patterns of transmission, research has focused on the relatedness of quantitative autism traits (QAT) between family members, mostly using questionnaires. Yet, different kinds of bias may influence research results. In this paper, we focus on possible informant effects and, taking these into account, on possible intergenerational transmission of QAT. This study used multiple informant data retrieved via the Social Responsiveness Scale from 170 families with at least one member with ASD. Using intraclass correlations (ICCs) and mixed model analyses, we investigated inter-informant agreement and differences between parent and teacher reports on children and between self- and other-reports on adults. Using structural equation modelling (SEM), we investigated the relatedness of QAT between family members in ASD families. Parent-teacher agreement about social responsiveness was poor, especially for children with ASD, though agreement between parents was moderate to strong for affected and unaffected children. Agreement between self- and other-report in adult men was good, but only moderate in women. Agreement did not differ between adults with and without ASD. While accounting for informant effects, our SEM results corroborated the assortative mating theory and the intergenerational transmission of QAT from both fathers and mothers to their offspring. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2014 | ||
| 690 | 7 | |a Autism spectrum disorders |2 nationallicence | |
| 690 | 7 | |a Intergenerational transmission |2 nationallicence | |
| 690 | 7 | |a Assortative mating |2 nationallicence | |
| 690 | 7 | |a Informant effect |2 nationallicence | |
| 690 | 7 | |a Informant contrast |2 nationallicence | |
| 700 | 1 | |a De la Marche |D Wouter |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | |
| 700 | 1 | |a Noens |D Ilse |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | |
| 700 | 1 | |a Kuppens |D Sofie |u HIVA - Research Institute for Work and Society, KU Leuven, Leuven, Belgium |4 aut | |
| 700 | 1 | |a Spilt |D Jantine |u School Psychology and Child and Adolescent Development Research Unit, KU Leuven, Leuven, Belgium |4 aut | |
| 700 | 1 | |a Boets |D Bart |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | |
| 700 | 1 | |a Steyaert |D Jean |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | |
| 773 | 0 | |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/4(2015-04-01), 385-395 |x 1018-8827 |q 24:4<385 |1 2015 |2 24 |o 787 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00787-014-0586-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00787-014-0586-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a De la Marche |D Wouter |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Noens |D Ilse |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kuppens |D Sofie |u HIVA - Research Institute for Work and Society, KU Leuven, Leuven, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Spilt |D Jantine |u School Psychology and Child and Adolescent Development Research Unit, KU Leuven, Leuven, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Boets |D Bart |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Steyaert |D Jean |u Leuven Autism Research (LAuRes), KU Leuven, Leuven, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/4(2015-04-01), 385-395 |x 1018-8827 |q 24:4<385 |1 2015 |2 24 |o 787 | ||