Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour
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| 024 | 7 | 0 | |a 10.1007/s00787-014-0567-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00787-014-0567-2 | ||
| 245 | 0 | 0 | |a Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour |h [Elektronische Daten] |c [Jennifer Richards, Catharina Hartman, Barbara Franke, Pieter Hoekstra, Dirk Heslenfeld, Jaap Oosterlaan, Alejandro Arias Vásquez, Jan Buitelaar] |
| 520 | 3 | |a The differential susceptibility theory states that children differ in their susceptibility towards environmental experiences, partially due to plasticity genes. Individuals carrying specific variants in such genes will be more disadvantaged in negative but, conversely, more advantaged in positive environments. Understanding gene-environment interactions may help unravel the causal mechanisms involved in multifactorial psychiatric disorders such as Attention-Deficit/Hyperactivity Disorder (ADHD). The differential susceptibility theory was examined by investigating the presence of interaction effects between maternal expressed emotion (EE; warmth and criticism) and the solitary and combined effects of plasticity genes (DAT1, DRD4, 5-HTT) on prosocial and antisocial behaviour (measured with parent- and self-reports) in children with ADHD and their siblings (N=366, M=17.11years, 74.9% male). Maternal warmth was positively associated with prosocial behaviour and negatively with antisocial behaviour, while maternal criticism was positively associated with antisocial behaviour and negatively with prosocial behaviour. No evidence of differential susceptibility was found. The current study found no evidence for differential susceptibility based on the selected plasticity genes, in spite of strong EE-behaviour associations. It is likely that additional factors play a role in the complex relationship between genes, environment and behaviour. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2014 | ||
| 690 | 7 | |a Maternal expressed emotion |2 nationallicence | |
| 690 | 7 | |a Antisocial behaviour |2 nationallicence | |
| 690 | 7 | |a Prosocial behaviour |2 nationallicence | |
| 690 | 7 | |a G×E interaction |2 nationallicence | |
| 700 | 1 | |a Richards |D Jennifer |u Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a Hartman |D Catharina |u Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |4 aut | |
| 700 | 1 | |a Franke |D Barbara |u Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a Hoekstra |D Pieter |u Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |4 aut | |
| 700 | 1 | |a Heslenfeld |D Dirk |u Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Oosterlaan |D Jaap |u Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands |4 aut | |
| 700 | 1 | |a Arias Vásquez |D Alejandro |u Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | |
| 700 | 1 | |a Buitelaar |D Jan |u Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | |
| 773 | 0 | |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/2(2015-02-01), 209-217 |x 1018-8827 |q 24:2<209 |1 2015 |2 24 |o 787 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00787-014-0567-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00787-014-0567-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Richards |D Jennifer |u Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hartman |D Catharina |u Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Franke |D Barbara |u Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hoekstra |D Pieter |u Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Heslenfeld |D Dirk |u Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oosterlaan |D Jaap |u Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arias Vásquez |D Alejandro |u Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Buitelaar |D Jan |u Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t European Child & Adolescent Psychiatry |d Springer Berlin Heidelberg |g 24/2(2015-02-01), 209-217 |x 1018-8827 |q 24:2<209 |1 2015 |2 24 |o 787 | ||