Effect of bias voltage and temperature on lifetime of wireless neural interfaces with Al2O3 and parylene bilayer encapsulation
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 60547947X | ||
| 003 | CHVBK | ||
| 005 | 20210128100410.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150201xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10544-014-9904-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10544-014-9904-y | ||
| 245 | 0 | 0 | |a Effect of bias voltage and temperature on lifetime of wireless neural interfaces with Al2O3 and parylene bilayer encapsulation |h [Elektronische Daten] |c [Xianzong Xie, Loren Rieth, Ryan Caldwell, Sandeep Negi, Rajmohan Bhandari, Rohit Sharma, Prashant Tathireddy, Florian Solzbacher] |
| 520 | 3 | |a The lifetime of neural interfaces is a critical challenge for chronic implantations, as therapeutic devices (e.g., neural prosthetics) will require decades of lifetime. We evaluated the lifetime of wireless Utah electrode array (UEA) based neural interfaces with a bilayer encapsulation scheme utilizing a combination of alumina deposited by Atomic Layer Deposition (ALD) and parylene C. Wireless integrated neural interfaces (INIs), equipped with recording version 9 (INI-R9) ASIC chips, were used to monitor the encapsulation performance through radio-frequency (RF) power and telemetry. The wireless devices were encapsulated with 52nm of ALD Al2O3 and 6μm of parylene C, and tested by soaking in phosphate buffered solution (PBS) at 57°C for 4× accelerated lifetime testing. The INIs were also powered continuously through 2.765MHz inductive power and forward telemetry link at unregulated 5V. The bilayer encapsulated INIs were fully functional for ∼35days (140days at 37°C equivalent) with consistent power-up frequencies (∼910MHz), stable RF signal (∼−75 dBm), and 100% command reception rate. This is ∼10 times of equivalent lifetime of INIs with parylene-only encapsulation (13days) under same power condition at 37°C. The bilayer coated INIs without continuous powering lasted over 1860 equivalent days (still working) at 37°C. Those results suggest that bias stress is a significant factor to accelerate the failure of the encapsulated devices. The INIs failed completely within 5days of the initial frequency shift of RF signal at 57°C, which implied that the RF frequency shift is an early indicator of encapsulation/device failure. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Neural interface |2 nationallicence | |
| 690 | 7 | |a Utah electrode array |2 nationallicence | |
| 690 | 7 | |a Atomic layer deposited (ALD) Al2O3 |2 nationallicence | |
| 690 | 7 | |a Parylene |2 nationallicence | |
| 690 | 7 | |a Bilayer encapsulation |2 nationallicence | |
| 690 | 7 | |a Continuous bias voltage |2 nationallicence | |
| 690 | 7 | |a Accelerated aging |2 nationallicence | |
| 690 | 7 | |a Long-term reliability |2 nationallicence | |
| 700 | 1 | |a Xie |D Xianzong |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 700 | 1 | |a Rieth |D Loren |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 700 | 1 | |a Caldwell |D Ryan |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 700 | 1 | |a Negi |D Sandeep |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 700 | 1 | |a Bhandari |D Rajmohan |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 700 | 1 | |a Sharma |D Rohit |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 700 | 1 | |a Tathireddy |D Prashant |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 700 | 1 | |a Solzbacher |D Florian |u University of Utah, Salt Lake City, UT, USA |4 aut | |
| 773 | 0 | |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-8 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10544-014-9904-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10544-014-9904-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Xie |D Xianzong |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rieth |D Loren |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Caldwell |D Ryan |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Negi |D Sandeep |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bhandari |D Rajmohan |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sharma |D Rohit |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tathireddy |D Prashant |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Solzbacher |D Florian |u University of Utah, Salt Lake City, UT, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Biomedical Microdevices |d Springer US; http://www.springer-ny.com |g 17/1(2015-02-01), 1-8 |x 1387-2176 |q 17:1<1 |1 2015 |2 17 |o 10544 | ||