Detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract: comparison of 18F-FDG PET/CT and MR imaging
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0283-x |2 doi |
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| 245 | 0 | 0 | |a Detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract: comparison of 18F-FDG PET/CT and MR imaging |h [Elektronische Daten] |c [Christian Maegerlein, Alexander Fingerle, Michael Souvatzoglou, Ernst Rummeny, Konstantin Holzapfel] |
| 520 | 3 | |a Purpose: Aim of our study was to compare the diagnostic performance of 18F-FDG PET/CT and MR imaging (MRI) in the detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract. Methods: A total of 49 patients with adenocarcinomas of the gastrointestinal tract who had undergone 18F-FDG PET/CT and MRI of the liver were included in this study. The MRI protocol included diffusion-weighted imaging and dynamic contrast-enhanced MR imaging after intravenous injection of Gd-DTPA. PET and MR images were analyzed by two experienced radiologists. Imaging results were correlated with histopathological findings or imaging follow-up as available. Sensitivities of both modalities were compared using McNemar Test. Receiver operating characteristic (ROC) curves were calculated to determine the diagnostic performance in correctly identifying liver metastases. Results: A total of 151 metastases were confirmed. For lesion detection, MRI was significantly superior to 18F-FDG PET/CT. Sensitivity of MRI in detecting metastases was 86.8% for Reader 1 (R1) and 87.4% for Reader 2 (R2), of PET/CT 66.2% for R1 and 68.2% for R2. Regarding only metastases with diameters of 10mm or less, sensitivities of MRI were 66.7% for R1 and 75.0% for R2, and were significantly higher than those of PET/CT (17.9% for R1 and 20.5% for R2). ROC analysis showed superiority for lesion classification of MRI as compared to 18F-FDG PET/CT. Conclusion: MRI is significantly superior to 18F-FDG PET/CT in the detection and classification of liver metastases in patients with adenocarcinomas of the gastrointestinal tract, especially in the detection of small metastases. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a 18F-FDG PET/CT |2 nationallicence | |
| 690 | 7 | |a Magnetic resonance imaging |2 nationallicence | |
| 690 | 7 | |a Diffusion-weighted MR imaging (DWI) |2 nationallicence | |
| 690 | 7 | |a Adenocarcinomas of the gastrointestinal tract |2 nationallicence | |
| 690 | 7 | |a Liver metastases |2 nationallicence | |
| 700 | 1 | |a Maegerlein |D Christian |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | |
| 700 | 1 | |a Fingerle |D Alexander |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | |
| 700 | 1 | |a Souvatzoglou |D Michael |u Department of Nuclear Medicine, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | |
| 700 | 1 | |a Rummeny |D Ernst |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | |
| 700 | 1 | |a Holzapfel |D Konstantin |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/5(2015-06-01), 1213-1222 |x 0942-8925 |q 40:5<1213 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0283-x |q text/html |z Onlinezugriff via DOI |
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| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0283-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maegerlein |D Christian |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fingerle |D Alexander |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Souvatzoglou |D Michael |u Department of Nuclear Medicine, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rummeny |D Ernst |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Holzapfel |D Konstantin |u Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/5(2015-06-01), 1213-1222 |x 0942-8925 |q 40:5<1213 |1 2015 |2 40 |o 261 | ||