Tyramine biosynthesis is transcriptionally induced at low pH and improves the fitness of Enterococcus faecalis in acidic environments
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| 024 | 7 | 0 | |a 10.1007/s00253-014-6301-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-014-6301-7 | ||
| 245 | 0 | 0 | |a Tyramine biosynthesis is transcriptionally induced at low pH and improves the fitness of Enterococcus faecalis in acidic environments |h [Elektronische Daten] |c [Marta Perez, Marina Calles-Enríquez, Ingolf Nes, Maria Martin, Maria Fernandez, Victor Ladero, Miguel Alvarez] |
| 520 | 3 | |a Enterococcus faecalis is a commensal bacterium of the human gut that requires the ability to pass through the stomach and therefore cope with low pH. E. faecalis has also been identified as one of the major tyramine producers in fermented food products, where they also encounter acidic environments. In the present work, we have constructed a non-tyramine-producing mutant to study the role of the tyramine biosynthetic pathway, which converts tyrosine to tyramine via amino acid decarboxylation. Wild-type strain showed higher survival in a system that mimics gastrointestinal stress, indicating that the tyramine biosynthetic pathway has a role in acid resistance. Transcriptional analyses of the E. faecalis V583 tyrosine decarboxylase cluster showed that an acidic pH, together with substrate availability, induces its expression and therefore the production of tyramine. The protective role of the tyramine pathway under acidic conditions appears to be exerted through the maintenance of the cytosolic pH. Tyramine production should be considered important in the adaptability of E. faecalis to acidic environments, such as fermented dairy foods, and to survive passage through the human gastrointestinal tract. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2014 | ||
| 690 | 7 | |a Enterococcus faecalis |2 nationallicence | |
| 690 | 7 | |a Tyramine |2 nationallicence | |
| 690 | 7 | |a tdc cluster expression |2 nationallicence | |
| 690 | 7 | |a Gastrointestinal stress |2 nationallicence | |
| 690 | 7 | |a Internal pH |2 nationallicence | |
| 700 | 1 | |a Perez |D Marta |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | |
| 700 | 1 | |a Calles-Enríquez |D Marina |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | |
| 700 | 1 | |a Nes |D Ingolf |u Norwegian University of Life Sciences UMB, Ås, Norway |4 aut | |
| 700 | 1 | |a Martin |D Maria |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | |
| 700 | 1 | |a Fernandez |D Maria |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | |
| 700 | 1 | |a Ladero |D Victor |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | |
| 700 | 1 | |a Alvarez |D Miguel |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/8(2015-04-01), 3547-3558 |x 0175-7598 |q 99:8<3547 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-014-6301-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-014-6301-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Perez |D Marta |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Calles-Enríquez |D Marina |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nes |D Ingolf |u Norwegian University of Life Sciences UMB, Ås, Norway |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Martin |D Maria |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Fernandez |D Maria |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ladero |D Victor |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Alvarez |D Miguel |u Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/8(2015-04-01), 3547-3558 |x 0175-7598 |q 99:8<3547 |1 2015 |2 99 |o 253 | ||