A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet
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| 024 | 7 | 0 | |a 10.1007/s00223-015-0057-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-0057-7 | ||
| 245 | 0 | 2 | |a A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet |h [Elektronische Daten] |c [Hyang Ok, Meron Gebreamanuel, Sang Oh, Hyejin Jeon, Won Lee, Oran Kwon] |
| 520 | 3 | |a The aim of this study was to evaluate the effects of a supplement containing Pueraria lobata/Rehmannia glutinosa (PR) root extracts on bone turnover in ovariectomized (OVX) rats (a model for postmenopausal osteoporosis). Female Sprague-Dawley rats (8weeks old) were randomized into eight groups: sham-operated rats with low-fat control diet+vehicle, OVX rats with low-fat control diet+vehicle, OVX rats with high-fat diet (HFD)+vehicle, OVX rats with HFD+vehicle+exercise, OVX rats with HFD+PR (400mg/kg body weight/day p.o.), OVX rats with HFD+PR+exercise, OVX rats with HFD+17β-estradiol (0.5mg/kg body weight/day p.o.), OVX rats with HFD+17β-estradiol+exercise. Bone microarchitecture, bone turnover markers (e.g., plasma alkaline phosphatase and osteocalcin), expressions of osteogenic and resorptive gene markers in the bone were measured. Eight weeks of PR and/or aerobic exercise improved cortical microarchitecture of the femur and decreased markers of bone turnover and expression of skeletal osteoclastogenic genes in the femur. PR supplementation combined with exercise preserved bone loss induced by estrogen deficiency and should be investigated further as an alternative to hormone replacement therapy for preventing osteoporosis in postmenopausal women. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Ovariectomy |2 nationallicence | |
| 690 | 7 | |a Postmenopausal |2 nationallicence | |
| 690 | 7 | |a Osteoporosis |2 nationallicence | |
| 690 | 7 | |a Pueraria lobata |2 nationallicence | |
| 690 | 7 | |a Rehmannia glutinosa |2 nationallicence | |
| 690 | 7 | |a Exercise |2 nationallicence | |
| 700 | 1 | |a Ok |D Hyang |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Gebreamanuel |D Meron |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Oh |D Sang |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Jeon |D Hyejin |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Lee |D Won |u Department of Exercise Science, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Kwon |D Oran |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/6(2015-12-01), 624-633 |x 0171-967X |q 97:6<624 |1 2015 |2 97 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-0057-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-0057-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ok |D Hyang |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gebreamanuel |D Meron |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Oh |D Sang |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jeon |D Hyejin |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Won |u Department of Exercise Science, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kwon |D Oran |u Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University, 120-750, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/6(2015-12-01), 624-633 |x 0171-967X |q 97:6<624 |1 2015 |2 97 |o 223 | ||