Fat Infiltration in the Leg is Associated with Bone Geometry and Physical Function in Healthy Older Women
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| 024 | 7 | 0 | |a 10.1007/s00223-015-0018-1 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00223-015-0018-1 | ||
| 245 | 0 | 0 | |a Fat Infiltration in the Leg is Associated with Bone Geometry and Physical Function in Healthy Older Women |h [Elektronische Daten] |c [Amanda Lorbergs, Michael Noseworthy, Jonathan Adachi, Paul Stratford, Norma MacIntyre] |
| 520 | 3 | |a The objective of this study was to estimate the associations between muscular fat infiltration, tibia bone mineral quantity and distribution, and physical function in healthy older women. Thirty-five women (aged 60-75years, mean 70years) were recruited from the community. Percent intramuscular fat (%IntraMF) within the right leg tibialis anterior, soleus, and gastrocnemius muscles and total intermuscular fat (IMF) were segmented from magnetic resonance imaging scans at the mid-calf. Intramyocellular lipid (IMCL) content in the right tibialis anterior was measured with proton magnetic resonance spectroscopy. Right tibia bone content, area, and strength were measured at the 4, 14, and 66% sites using peripheral quantitative computed tomography. Physical function was assessed by gait speed on the 20m walking test. After adjusting for age, body size, and activity level, %IntraMF had a negative association with bone content and area at all tibia sites (r=−0.31 to −0.03). Conversely, greater IMF was associated with increased bone content and area (r=0.04-0.32). Correlation coefficients for the association between IMCL and bone were negative (r=−0.44 to −0.03). All measures of fat infiltration had a negative association with observed physical function (r=−0.42 to −0.04). Our findings suggest that muscular fat infiltration in the leg of healthy postmenopausal women has a compartment-specific relationship with bone status and physical function. Minimizing fat accumulation within and between muscle compartments may prevent bone fragility and functional decline in women. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Aged |2 nationallicence | |
| 690 | 7 | |a Adipose tissue |2 nationallicence | |
| 690 | 7 | |a Magnetic resonance imaging (MRI) |2 nationallicence | |
| 690 | 7 | |a Proton magnetic resonance spectroscopy (1H MRS) |2 nationallicence | |
| 690 | 7 | |a X-ray computed tomography |2 nationallicence | |
| 690 | 7 | |a Mobility limitation |2 nationallicence | |
| 700 | 1 | |a Lorbergs |D Amanda |u Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, 1200 Centre St., Rm. 620, 02131, Boston, MA, USA |4 aut | |
| 700 | 1 | |a Noseworthy |D Michael |u School of Biomedical Engineering, McMaster University, 1280 Main Street West, ETB 406, L8S 4K1, Hamilton, ON, Canada |4 aut | |
| 700 | 1 | |a Adachi |D Jonathan |u Department of Medicine, McMaster University, 501-25 Charlton Ave East, L8N 1Y2, Hamilton, ON, Canada |4 aut | |
| 700 | 1 | |a Stratford |D Paul |u School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada |4 aut | |
| 700 | 1 | |a MacIntyre |D Norma |u School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada |4 aut | |
| 773 | 0 | |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/4(2015-10-01), 353-363 |x 0171-967X |q 97:4<353 |1 2015 |2 97 |o 223 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00223-015-0018-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00223-015-0018-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lorbergs |D Amanda |u Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, 1200 Centre St., Rm. 620, 02131, Boston, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Noseworthy |D Michael |u School of Biomedical Engineering, McMaster University, 1280 Main Street West, ETB 406, L8S 4K1, Hamilton, ON, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Adachi |D Jonathan |u Department of Medicine, McMaster University, 501-25 Charlton Ave East, L8N 1Y2, Hamilton, ON, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Stratford |D Paul |u School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a MacIntyre |D Norma |u School of Rehabilitation Science, McMaster University, 1400 Main Street West, IAHS 403, L8S 1C7, Hamilton, ON, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Calcified Tissue International |d Springer US; http://www.springer-ny.com |g 97/4(2015-10-01), 353-363 |x 0171-967X |q 97:4<353 |1 2015 |2 97 |o 223 | ||